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Abz-(Asn⁶⁷⁰,Leu⁶⁷¹)-Amyloid β/A4 Protein Precursor₇₇₀ (669-674)-EDDnp trifluoroacetate salt
Abz-Val-Asn-Leu-Asp-Ala-Glu-EDDnp trifluoroacetate salt

M-2565

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
M-2565.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 134.00
CHF 124.62 (7%)
M-2565.0005 5 mg Ships within 3-5 business days  
CHF 536.00
CHF 498.48 (7%)
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Details

Intramolecularly quenched fluorescent substrate containing the ortho-aminobenzoyl (Abz) / N-(2,4-dinitrophenyl)ethylenediamine (EDDnp) groups as the donor / acceptor pair. It corresponds to the Swedish-mutated (JMV2236) β-amyloid precursor protein (βAPP) sequence targeted by β-secretase BACE (β-site APP-cleaving activity). This FRET substrate is more selectively cleaved by BACE1 and BACE2 than by cathepsin D, a disintegrin and metalloprotease 10 (ADAM10), tumor necrosis α-converting enzyme (TACE), presenilin-1 (PS1), or presenilin-2 (PS2).
Item Number 4045326
Synonyms JMV2236, Abz-(Asn⁶⁷⁰,Leu⁶⁷¹)-APP₇₇₀ (669-674)-EDDnp
Molecular Formula C₄₂H₅₈N₁₂O₁₆
Relative Molecular Mass 986.99
CAS Registry Number [1007306-20-8] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease

M-2565

Enzyme Substrates Inhibitors
β-Secretase