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Mca-(Ala⁷,Lys(Dnp)⁹)-Bradykinin trifluoroacetate salt
Mca-Arg-Pro-Pro-Gly-Phe-Ser-Ala-Phe-Lys(Dnp)-OH trifluoroacetate salt

M-2405

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
M-2405.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 577.00
CHF 536.61 (7%)
M-2405.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 2'307.00
CHF 2'145.51 (7%)
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Details

Substrate V, Mca-RPPGFSAFK(Dnp), is a very sensitive internally quenched fluorescent substrate for endothelin-converting enzyme-1 (ECE-1) a membrane-bound zinc metallopeptidase that is related to neprilysin in amino acid sequence. The kcat/Km value for the hydrolysis by ECE-1 was 1.9 x 10⁷ M⁻¹s⁻¹ and 1.7 x 10⁶ M⁻¹s⁻¹ for the hydrolysis by neprilysin.
This FRET substrate was hydrolyzed rapidly by stromelysin 1 (MMP-3) with kcat/Km= 218000 M⁻¹s⁻¹ and very slowly by gelatinase B (MMP-9) (kcat/Km= 10100 M⁻¹s⁻¹). There was no hydrolysis by MMP-1 and MMP-2. Mca-RPPGFSAFK(Dnp) has also found use as substrate for insulin-degrading enzyme (IDE) and ACE2.
Item Number 4029459
APC Number 81-3-32
Molecular Formula C₆₆H₈₁N₁₅O₁₉
Relative Molecular Mass 1388.46
CAS Registry Number [323577-36-2] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords ECE substrate

M-2405

Enzyme Substrates Inhibitors
β-Secretase    
Matrix Metalloproteinase-3 (MMP-3)    
Matrix Metalloproteinase-9 (MMP-9)    
Endothelin-Converting Enzyme 1    
Angiotensin I-Converting Enzyme (ACE)    
Angiotensin-Converting Enzyme 2    
Insulysin    
Neprilysin    
Thimet Oligopeptidase    
Stromelysin 1