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Availability: In stock

Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH₂ trifluoroacetate salt

M-2350

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
M-2350.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 294.00
CHF 273.42 (7%)
M-2350.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1,177.00
CHF 1,094.61 (7%)
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Details

The N-terminal elongation of the widely used MMP FRET substrate Mca-PLGL-Dpa-AR-NH₂ (M-1895) with a Lys yields a fluorogenic peptide with improved substrate properties. As compared to M-1895, the specificity constant (kcat/Km) of the broad-spectrum MMP-substrate M-2350, Mca-KPLGL-Dpa-AR-NH₂ for collagenases (MMP-1, MMP-8, MMP-13) and MMP-14 is increased two- to ninefold and threefold, respectively, while those for gelatinases and matrilysin remain equally high.
Item Number 4028885
One Letter Code Mca-KPLGL-Dpa-AR-NH₂
Molecular Formula C₅₅H₈₀N₁₆O₁₆
Relative Molecular Mass 1221.34
CAS Registry Number [720710-69-0] net
Source Synthetic
Storage Conditions -20 ± 5 °C

M-2350

Enzyme Substrates Inhibitors
Interstitial Collagenase    
Gelatinase A    
Stromelysin 1    
Matrilysin    
Collagenase-2    
Gelatinase B    
Collagenase-3    
Matrix Metalloproteinase-14 (MMP-14)    
Matrix Metalloproteinase-2 (MMP-2)    
Matrix Metalloproteinase-1 (MMP-1)    
Matrix Metalloproteinase-7 (MMP-7)    
Matrix Metalloproteinase-3 (MMP-3)    
Matrix Metalloproteinase-8 (MMP-8)    
Matrix Metalloproteinase-9 (MMP-9)    
Matrix Metalloproteinase-13 (MMP-13)    
Matrix Metalloproteinase-20 (MMP-20)    
ADAM17 Endopeptidase