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Availability: In stock

H-Asn-Glu-Ala-Tyr-Val-His-Asp-Ala-Pro-Val-Arg-Ser-Leu-Asn-OH

M-1890

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
M-1890.0001 1 mg Ships within 1 business day  
CHF 155.00
CHF 144.15 (7%)
M-1890.0005 5 mg Ships within 3-5 business days  
CHF 618.00
CHF 574.74 (7%)
M-1890.0025 25 mg Ships within 3-5 business days  
CHF 2'472.00
CHF 2'298.96 (7%)
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Details

IL-1β converting enzyme (ICE, now called caspase-1), a cytosolic enzyme, is responsible for the cleavage of the inactive precursor protein to the active IL-1β. Similarly, caspase-1 hydrolyzes this 14-amino acid peptide that corresponds to the native cleavage site sequence around Asp¹¹⁶-Ala¹¹⁷. The peptide is also able to inhibit the cleavage of the precursor to the mature protein.
Item Number 4030474
APC Number 81-6-80
One Letter Code NEAYVHDAPVRSLN
Synonyms H-NEAYVHDAPVRSLN-OH, N-E-A-Y-V-H-D-A-P-V-R-S-L-N
Molecular Formula C₆₈H₁₀₅N₂₁O₂₃
Relative Molecular Mass 1584.71
CAS Registry Number [143305-11-7]
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords ICE substrate
Areas of Interest Apoptosis & Necrosis

Product citations

J.R.Weidner et al., Peptides, Chemistry and Biology, Proceedings of the 12th American Peptide Symposium, Cambridge, MA, p. 891, J.A.Smith and J.E.Rivier, eds., Escom, Leiden, (1992)

M-1890

Enzyme Substrates Inhibitors
Caspase-1 (ICE)