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α-Synuclein (67-78) (human) trifluoroacetate salt
H-Gly-Gly-Ala-Val-Val-Thr-Gly-Val-Thr-Ala-Val-Ala-OH trifluoroacetate salt

H-8384

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-8384.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 145.00
CHF 134.85 (7%)
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Details

The Parkinson's disease-associated protein α-synuclein (α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. Two distinct cholesterol-binding domains in α-synuclein were identified by Fantini and coworkers. The tilted peptide of α-synuclein (67-78) bound cholesterol with high affinity and was toxic for cultured astrocytes. A cholesterol recognition consensus motif with lower affinity for cholesterol and devoid of toxicity, is encased in the glycosphingolipid-binding domain (34-45) of α-synuclein. The authors propose that the association of α-synuclein with lipid rafts involves both the binding of α-synuclein (34-45) to glycosphingolipids, and the interaction of α-synuclein (67-78) with cholesterol.
Item Number 4107368
One Letter Code GGAVVTGVTAVA
Molecular Formula C₄₃H₇₆N₁₂O₁₅
Relative Molecular Mass 1001.14
Source Synthetic
Storage Conditions -20 ± 5 °C