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α-Synuclein (34-45) (human) trifluoroacetate salt
H-Lys-Glu-Gly-Val-Leu-Tyr-Val-Gly-Ser-Lys-Thr-Lys-OH trifluoroacetate salt


Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-8382.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 148.00
CHF 137.64 (7%)
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The Parkinson's disease-associated protein α-synuclein (α-syn) is not only expressed in the cytoplasm of neurons, but also secreted in the extracellular space and internalized into glial cells through a lipid raft dependent process. Two distinct cholesterol-binding domains in α-synuclein were identified by Fantini and coworkers. The tilted peptide of α-synuclein (67-78) bound cholesterol with high affinity and was toxic for cultured astrocytes. A cholesterol recognition consensus motif with lower affinity for cholesterol and devoid of toxicity, is encased in the glycosphingolipid-binding domain (34-45) of α-synuclein. The authors propose that the association of α-synuclein with lipid rafts involves both the binding of α-synuclein (34-45) to glycosphingolipids, and the interaction of α-synuclein (67-78) with cholesterol.
Item Number 4107367
Molecular Formula C₅₉H₁₀₁N₁₅O₁₈
Relative Molecular Mass 1308.52
Source Synthetic
Storage Conditions -20 ± 5 °C