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(Ser(PO₃H₂)²⁷³)-Nek11 (268-283) trifluoroacetate salt
H-Leu-Asn-Lys-Asn-Pro-Ser(PO₃H₂)-Leu-Arg-Pro-Ser-Ala-Ile-Glu-Ile-Leu-Cys-OH trifluoroacetate salt

H-8312

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-8312.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 230.00
CHF 213.90 (7%)
H-8312.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 395.00
CHF 367.35 (7%)
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Details

Depletion of NEK11 prevents proteasome-dependent degradation of CDC25A, both in unperturbed and DNA-damaged cells. In addition, NEK11 directly phosphorylates CDC25A, and CHK1 (checkpoint kinase 1) directly activates NEK11 by phosphorylating it on Ser²⁷³. Taken together, NEK11 is an important component of the pathway enforcing the G2/M checkpoint, and genetic mutations in NEK11 may contribute to the development of cancer. These results have been shown by Melixetian and coworkers.
Item Number 4104897
One Letter Code LNKNP(p)SLRPSAIEILC
Molecular Formula C₇₇H₁₃₅N₂₂O₂₆PS
Relative Molecular Mass 1848.09
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Cancer Research