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Uroguanylin Topoisomer B (human) trifluoroacetate salt
H-Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH trifluoroacetate salt
(Disulfide bonds between Cys⁴ and Cys¹²/Cys⁷ and Cys¹⁵)

H-8142

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-8142.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 433.00
CHF 402.69 (7%)
H-8142.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 773.00
CHF 718.89 (7%)
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Details

Short peptides containing two disulfide bridges can form interconvertible topoisomers with the same disulfide connectivity. In case of uroguanylin (UGN), both are relatively stable and can be separated, and interconversion is slow. The topoisomers differ in biological activity: The UGN A topomer potently activates the guanylate cyclase C receptor found primarily in the intestine. The B topomer is a very weak agonist of this receptor. Moss et al. could show that UGN B has potent natriuretic activity in the kidney.
Item Number 4059285
One Letter Code NDDCELCVNVACTGCL
Synonyms UGN Topoisomer B (human)
Molecular Formula C₆₄H₁₀₂N₁₈O₂₆S₄
Relative Molecular Mass 1667.88
Source Synthetic
Storage Conditions -20 ± 5 °C