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C5a Inhibitory Sequence
H-Phe-Lys-Ala-β-cyclohexyl-Ala-β-cyclohexyl-Ala-Leu-D-Ala-Arg-OH

H-8135

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-8135.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 577.00
CHF 536.61 (7%)
H-8135.0025 25 mg Ships within 1 business day  
CHF 2'307.00
CHF 2'145.51 (7%)
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Details

The C5a-related octapeptide Phe-Lys-Ala-Cha-Cha-Leu-D-Ala-Arg possesses a high binding affinity for polymorphonuclear leukocyte membranes (Ki = 0.09 µM). It has therefore been used as a leading analog for the development of specific C5a antagonists, which are of considerable therapeutic interest for the treatment of inflammatory disorders and tissue damage.
Item Number 4030450
Molecular Formula C₅₁H₈₆N₁₂O₉
Relative Molecular Mass 1011.32
CAS Registry Number [133214-60-5]
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Model for C5a antagonists
Areas of Interest Inflammation Research

Product citations

M.Kawai et al., Poster (abstr. P-525) presented at the 12th American Peptide Symposium, Cambridge, MA, (1991)