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WRW4 trifluoroacetate salt
H-Trp-Arg-Trp-Trp-Trp-Trp-NH₂ trifluoroacetate salt

H-7596

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-7596.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 70.00
CHF 65.10 (7%)
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Details

Antagonist of formyl peptide receptor-like 1 (FPRL1) signalling. WRW4 inhibits WKYMVm binding to FPRL1 (IC₅₀ 0.23 mM) as well as the intracellular calcium release induced by WKYMVm, MMK-1, amyloid β42, and F peptide. The tryptophan-rich peptide also inhibits FPRL1-mediated signalling in human neutrophils and blocks chemotactic migration and superoxide generation by Aβ42. WRW4 inhibited the activation of FPRL2 by F2L (H-6294), an FPRL2-selective endogenous agonist, resulting in the complete inhibition of intracellular calcium increase and chemotactic migration.
Item Number 4095537
APC Number 15-1-16
One Letter Code WRWWWW-NH₂
Molecular Formula C₆₁H₆₅N₁₅O₆
Relative Molecular Mass 1104.27
CAS Registry Number [878557-55-2] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease