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Angiotensin A (1-7) trifluoroacetate salt
H-Ala-Arg-Val-Tyr-Ile-His-Pro-OH trifluoroacetate salt

H-7424

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-7424.0010 10 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 125.00
CHF 116.25 (7%)
H-7424.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 250.00
CHF 232.50 (7%)
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Details

Alamandine can be formed from angiotensin A by action of ACE-2 or directly from angiotensin-(1-7) by decarboxylation of its aspartate residue. The angiotensin A analog produces effects resembling those of Ang II (1-7). However, it acts independently of the two known vasodilators receptors of the RAS (Mas and angiotensin II type 2). To produce its effects, alamandine binds to the Mas-related receptor, MrgD. A novel orally active formulation of alamandine produced a long-term antihypertensive effect in spontaneously hypertensive rats and cardioprotective effects. These novel findings will be helpful for developing a new understanding of the RAS, a key regulator of blood pressure and fluid balance. The heptapeptide could serve as a model peptide, e.g. in the development and evaluation of analytical methods.
Item Number 4084113
One Letter Code ARVYIHP
Synonyms Alamandine, (Ala¹)-Angiotensin I/II (1-7)
Molecular Formula C₄₀H₆₂N₁₂O₉
Relative Molecular Mass 855.01
CAS Registry Number [1176306-10-7] net
Source Synthetic
Storage Conditions -20 ± 5 °C