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(Pyr³)-Amyloid β-Protein (3-40) trifluoroacetate salt
Pyr-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH trifluoroacetate salt

H-7422

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-7422.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 250.00
CHF 232.50 (7%)
H-7422.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 440.00
CHF 409.20 (7%)
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Details

The pyroglutamate-modified amyloid-β peptides derived from Aβ40 (H-7422) and Aβ42 (H-4796) have gained considerable attention as potential key participants in the pathology of Alzheimer's disease (AD) due to their abundance in AD brain, high aggregation propensity, stability, and cellular toxicity. Aβ40 and 42 can be N-terminally truncated by action of cathepsin B. The cyclization of Glu³ is catalyzed by glutaminyl cyclase. Hence, inhibition of these enzymes could be a therapeutic approach to AD.
Item Number 4050043
One Letter Code pEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVV
Molecular Formula C₁₈₇H₂₈₃N₅₁O₅₃S
Relative Molecular Mass 4125.68
CAS Registry Number [161818-04-8] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease