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(Nle³⁵)-Amyloid β-Protein (1-40) ammonium salt
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Nle-Val-Gly-Gly-Val-Val-OH ammonium salt

H-7312

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-7312.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 149.00
CHF 138.57 (7%)
H-7312.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 249.00
CHF 231.57 (7%)
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Details

The reactive thioether of Met³⁵ is crucial for the activity of Aβ 1-40 and Aβ 1-42. Due to the replacement of Met by inert Nle, M35Nle Aβ 1-40 was no longer toxic to cultured hippocampal neurons and had little effect on the level of protein carbonyl residues. The Nle peptide showed the same propensity to aggregate, whereas sulfoxide formation hindered the required conformational transition from random coil to β-sheet.
Item Number 4041778
Synonyms (Nle³⁵) β-Amyloid (1-40)
Molecular Formula C₁₉₅H₂₉₇N₅₃O₅₈
Relative Molecular Mass 4311.83
CAS Registry Number [1802086-31-2]
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease