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(D-Arg¹,D-Phe⁵,D-Trp⁷·⁹,Leu¹¹)-Substance P
H-D-Arg-Pro-Lys-Pro-D-Phe-Gln-D-Trp-Phe-D-Trp-Leu-Leu-NH₂

H-6935

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-6935.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 82.00
CHF 76.26 (7%)
H-6935.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 330.00
CHF 306.90 (7%)
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Details

(D-Arg¹,D-Phe⁵,D-Trp⁷·⁹,Leu¹¹)-Substance P initially described as a low potency ghrelin receptor antagonist has surprisingly been found to be a full inverse agonist (EC₅₀ = 5.2 nM). In COS-7 cells transiently transfected with the ghrelin receptor the substance P analog rPKPfQwFwLL decreased the constitutive signaling down to levels observed in untransfected cells. Assuming that constitutive signaling of the ghrelin receptor is of physiological relevance in the regulation of appetite control, inverse agonists of the ghrelin receptor could be interesting for the treatment of obesity. So, Asakawa et al. found that peripherally administered H-6395 decreased food intake in lean mice, in mice with diet induced obesity, and in ob/ob obese mice.
Item Number 4013823
APC Number 70-9-18
One Letter Code rPKPfQwFwLL-NH₂
Synonyms [DArg1, DPhe5, DTrp7,9, Leu11] Substance P
Molecular Formula C₇₉H₁₀₉N₁₉O₁₂
Relative Molecular Mass 1516.86
CAS Registry Number [96736-12-8]
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Inverse agonist of ghrelin
Areas of Interest Obesity Research