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(Gly²¹)-Amyloid β-Protein (1-40) trifluoroacetate salt
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Gly-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH trifluoroacetate salt

H-6702

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-6702.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 155.00
CHF 144.15 (7%)
H-6702.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 257.00
CHF 239.01 (7%)
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Details

Contrary to β-amyloid peptides mutated at position 22 (Dutch, Italian, Arctic mutants) the Flemish mutation (A21G) shows a decreased tendency to aggregate and a reduced neurotoxicity. In the studies of Betts and Tsubuki, A21G was degraded significantly more slowly by neprilysin than the wild-type Aβ 1-40 and the E22 mutants. The relative resistance to proteolytic degradation may account for the pathogenicity of the Aβ mutant.
Item Number 4039927
APC Number 62-0-61
One Letter Code DAEFRHDSGYEVHHQKLVFFGEDVGSNKGAIIGLMVGGVV
Synonyms Amyloid β-Protein (1-40) Flemish Mutation, Amyloid β-Protein (1-40) A21G, [Gly21] β-Amyloid (1-40)
Molecular Formula C₁₉₃H₂₉₃N₅₃O₅₈S
Relative Molecular Mass 4315.84
CAS Registry Number [154362-03-5] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease