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Smac-N7 Peptide trifluoroacetate salt
H-Ala-Val-Pro-Ile-Ala-Gln-Lys-OH trifluoroacetate salt

H-6656

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-6656.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 113.00
CHF 105.09 (7%)
H-6656.0005 5 mg Ships within 3-5 business days  
CHF 453.00
CHF 421.29 (7%)
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Details

Smac-N7 Peptide corresponds to the N-terminal seven residues of Smac (second mitochondria-derived activator of caspase) also known as DIABLO. Smac/DIABLO is a mitochondrial proapoptotic protein that activates caspases in the cytochrome c/Apaf-1/caspase-9 pathway by neutralizing inhibitor of apoptosis protein (IAP).
Smac-N7 peptide promoted procaspase-3 activation in vitro at around 10 µM and inhibited binding of caspase-9-p12 to the BIR3 (baculoviral IAP repeat 3) domain of XIAP (X-linked IAP).
The finding that Smac/DIABLO agonists could enhance the apoptosis-inducing potential of irradiation and chemotherapeutic drugs might lead to promising new candidates for cancer treatment.
Item Number 4063291
One Letter Code AVPIAQK
Synonyms Mitochondrial Diablo Homolog (1-7) (human, mouse), Second Mitochondria-derived Activator of Caspase (1-7) (human, mouse), Smac Protein (1-7) (human, mouse)
Molecular Formula C₃₃H₅₉N₉O₉
Relative Molecular Mass 725.89
CAS Registry Number [401913-57-3] net
Source Synthetic
Storage Conditions -20 ± 5 °C