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(7-Diethylaminocoumarin-3-yl)carbonyl-Amyloid β-Protein (1-40) trifluoroacetate salt
(7-Diethylaminocoumarin-3-yl)carbonyl-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH trifluoroacetate salt

H-6468

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-6468.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 195.00
CHF 181.35 (7%)
H-6468.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 361.00
CHF 335.73 (7%)
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Details

Amyloid β-protein (1-40) that is N-terminally modified with the fluorescent dye (7-diethylaminocoumarin-3-yl)carbonyl (DAC or DEAC). This derivative can be utilized to assess the binding properties of amyloid β-protein (1-40) for various membranes since it behaves very similar to the native peptide. In aqueous environments the fluorophore is almost non-fluorescent whereas binding to membranes results in an increase in fluorescence intensity (λex = 430 nm, λem = 470 nm). Increases in the GM1 ganglioside and cholesterol content in the lipid bilayers facilitated the binding of this peptide. For phosphatidylcholine and phosphatidylserine no affinity was observed.
Item Number 4048251
Synonyms DAC-Amyloid β-Protein (1-40)
Molecular Formula C₂₀₈H₃₀₈N₅₄O₆₁S
Relative Molecular Mass 4573.13
CAS Registry Number [1802087-66-6] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease