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Myelin Basic Protein (85-99) Peptide Antagonist trifluoroacetate salt
H-Glu-Lys-Pro-Lys-Val-Glu-Ala-Tyr-Lys-Ala-Ala-Ala-Ala-Pro-Ala-OH trifluoroacetate salt

H-6292

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-6292.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 309.00
CHF 287.37 (7%)
H-6292.0005 5 mg Ships within 3-5 business days  
CHF 1'236.00
CHF 1'149.48 (7%)
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Details

The antagonistic 15-peptide EKPKVEAYKAAAAPA competes with MBP (85-99), the immunodominant epitope of myelin basic protein (MBP), a major candidate autoantigen in multiple sclerosis (MS), for binding to human leukocyte antigen (HLA)-DR2. The peptide also inhibits IL-2 secretion by MBP (85-99) specific T-cell clones and induces the production of Th2 cytokines by splenocytes. Furthermore, it could be shown that the peptide is able to suppress experimental autoimmune encephalomyelitis (EAE) in several models in a manner that is equipotent to random amino acid copolymers, such as Copaxone [poly (Y,E,A,K)n]. Therefore, this synthetic peptide might be suitable in the studying of MS.
Item Number 4049448
One Letter Code EKPKVEAYKAAAAPA
Synonyms MBP (85-99) Peptide Antagonist
Molecular Formula C₇₀H₁₁₄N₁₈O₂₁
Relative Molecular Mass 1543.78
CAS Registry Number [444305-16-2] net
Source Synthetic
Storage Conditions -20 ± 5 °C