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Acetyl-(Pro¹⁸,Asp²¹)-Amyloid β-Protein (17-21) amide
Ac-Leu-Pro-Phe-Phe-Asp-NH₂

H-6138

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-6138.0005 5 mg Ships within 3-5 business days  
CHF 70.00
CHF 65.10 (7%)
H-6138.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 267.00
CHF 248.31 (7%)
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Details

The pentapeptide Ac-LPFFD-NH₂ (iAβ5p) is an analog of product H-4876 with small chemical modifications which enhance its stability against proteolytic degradation. iAβ5p acts as a β-sheet breaker peptide and crosses the blood-brain barrier at a higher rate than most proteins and peptides known to be selectively taken up by the brain so that it is assumed that the peptide is being specifically transported to the brain. A significant increase in neuronal survival and decrease in brain inflammation associated with the reduction of amyloid plaques in two different transgenic Alzheimer`s disease (AD) models is additionally reported for iAβ5p.
Item Number 4045708
APC Number 62-0-18
One Letter Code Ac-LPFFD-NH₂
Synonyms iAβ5p, Beta-sheet Breaker Peptide βiA 5p
Molecular Formula C₃₅H₄₆N₆O₈
Relative Molecular Mass 678.79
CAS Registry Number [339990-02-2]
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease