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Retrocyclin-1 trifluoroacetate salt
Cyclo(-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg-Gly-Ile-Cys-Arg-Cys-Ile-Cys-Gly-Arg) trifluoroacetate salt
(Disulfide bonds between Cys³ and Cys¹⁶/Cys⁵ and Cys¹⁴/Cys⁷ and Cys¹²)

H-6126

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-6126.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 247.00
CHF 229.71 (7%)
H-6126.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 412.00
CHF 383.16 (7%)
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Details

The theta-defensin retrocyclin-1, also called RC-100, is a circular octadecapeptide containing an internal trisulfide ladder. Besides its antimicrobial activity, retrocyclin-1 has a remarkable ability to protect human cells in vitro from infection by T- and M-tropic strains of HIV-1. Its effectiveness against HIV-1 results from the prevention of viral entry, and is correlated with its ability to recognize and bind with high affinity to glycoproteins and glycolipids implicated in HIV-1 entry, such as gp120 (KD = 35.4 nM), CD4 (KD = 31 nM), and galactosylceramide (KD = 24.1 nM). Retrocyclin represents a new class of small molecule HIV-1 entry inhibitors.
Item Number 4045698
Synonyms RC-100
Molecular Formula C₇₄H₁₂₈N₃₀O₁₈S₆
Relative Molecular Mass 1918.42
CAS Registry Number [724760-19-4] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Antimicrobial peptide with anti-HIV activity