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Tumor Targeted Pro-Apoptotic Peptide trifluoroacetate salt
H-Cys-Asn-Gly-Arg-Cys-Gly-Gly-D-Lys-D-Leu-D-Ala-D-Lys-D-Leu-D-Ala-D-Lys-D-Lys-D-Leu-D-Ala-D-Lys-D-Leu-D-Ala-D-Lys-NH₂ trifluoroacetate salt
(Disulfide bond)

H-6104

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-6104.0001 1 mg Ships within 3-5 business days  
CHF 237.00
CHF 220.41 (7%)
H-6104.0005 5 mg Request lead time  
CHF 948.00
CHF 881.64 (7%)
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Details

Tumor targeted pro-apoptotic peptide consists of two functional domains, on the one hand a "homing" or targeting domain, which guides the peptide to targeted cells and allows its internalization and on the other hand a programmed cell death-inducing sequence. The targeting domain contains the Asn-Gly-Arg (NGR) motif which has proven useful for delivering various anti-tumor compounds and viral particles to tumor vessels. As programmed cell death-inducing sequence the synthetic 14 amino acid peptide klaklakklaklak, also called (klaklak)₂, was selected, because it kills bacteria at concentrations 1% of those required to kill eukaryotic cells. This pro-apoptotic domain is non-toxic outside of cells, but toxic when internalized into targeted cells by the disruption of mitochondrial membranes. Therefore, targeted pro-apoptotic peptides represent a potential new class of anti-cancer agents. They combine two levels of specificity: "homing" to targeted cells and selective apoptosis of such cells after entry.
Item Number 4045167
One Letter Code CNGRCGGklaklakklaklak-NH₂
Synonyms CNGRC-GG-(klaklak)₂-NH₂ (Disulfide bond)
Molecular Formula C₉₄H₁₇₄N₃₂O₂₂S₂
Relative Molecular Mass 2168.75
CAS Registry Number [1926163-30-5] net
Source Synthetic
Storage Conditions -20 ± 5 °C