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6-FAM-AEEAc-Stichodactyla helianthus Neurotoxin (ShK) trifluoroacetate salt
Fluorescein-6-carbonyl-AEEAc-Arg-Ser-Cys-Ile-Asp-Thr-Ile-Pro-Lys-Ser-Arg-Cys-Thr-Ala-Phe-Gln-Cys-Lys-His-Ser-Met-Lys-Tyr-Arg-Leu-Ser-Phe-Cys-Arg-Lys-Thr-Cys-Gly-Thr-Cys-OH trifluoroacetate salt
(Disulfide bonds between Cys³ and Cys³⁵/Cys¹² and Cys²⁸/Cys¹⁷ and Cys³²)

H-6088

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-6088.0100 0.1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 399.00
CHF 371.07 (7%)
H-6088.0500 0.5 mg Ships within 3-5 business days  
CHF 1,576.00
CHF 1,465.68 (7%)
H-6088.1000 1 mg Ships within 3-5 business days  
CHF 2,732.00
CHF 2,540.76 (7%)
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Details

This ShK analog containing a fluorescein-6-carboxyl group attached through an {2-[2-aminoethoxy]ethoxy}acetic acid (AEEAc) linker to the ƒ-amino group of Arg¹, selectively blocked the voltage gated T-lymphocyte K⁺ Kv1.3 channels implicated in the pathogenesis of experimental autoimmune encephalomyelitis. It potently blocked Kv1.3 channels at picomolar concentrations and exhibited >80 fold specificity for Kv1.3 over Kv1.1 and other Kv channels. In flow cytometry experiments, chronically activated rat and human T-lympocytes with >600 Kv1.3 channels/cell were readily distinguished from resting and acutely activated T-lymphocytes with lower Kv1.3 channel numbers. 6-FAM-AEEAc-Stichodactyla helianthus neurotoxin (ShK) may therefore be a useful tool to detect the presence of T-lymphocytes with high expression of Kv1.3 channels in normal and diseased tissues.
Item Number 4044280
Synonyms 6-FAM-AEEAc-ShK, ShK-F6CA
Molecular Formula C₁₉₆H₂₉₅N₅₅O₅₇S₇
Relative Molecular Mass 4558.30
CAS Registry Number [1927927-42-1] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Ion Channel Modulating Agents