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ent-[Amyloid β-Protein (20-16)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)]) trifluoroacetate salt
H-D-Phe-D-Phe-D-Val-D-Leu-D-Lys-β-Ala-D-Lys(D-Lys-D-Leu-D-Val-D-Phe-D-Phe-H)-OH trifluoroacetate salt

H-6074

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-6074.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 70.00
CHF 65.10 (7%)
H-6074.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 165.00
CHF 153.45 (7%)
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Details

This all-D peptide contains two retro-inverso peptide klvff motifs of KLVFF (H-3682) corresponding to amino acids 16 to 20 of amyloid β-protein. The tandem dimer retro-inverso peptide showed about a 100-fold higher binding affinity (Kd = 1.3 · 10⁻² µM) for amyloid β-protein (1-40) fibrils than KLVFF (Kd = 1.1 ± 0.3 µM). It was also found to be more effective in preventing ordered fibril formation than the parent peptide KLVFF as judged by its increased ability to inhibit thioflavin T binding to β-sheet structures.
Item Number 4044533
Synonyms ent-[retro-Amyloid β-Protein (16-20)]-β-Ala-D-Lys(ent-[Amyloid β-Protein (16-20)]), (ffvlk)₂(βA)k (tandem dimer)
Molecular Formula C₇₉H₁₁₉N₁₅O₁₃
Relative Molecular Mass 1486.91
CAS Registry Number [1426174-31-3] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease