Shopping Cart - CHF 0.00

You have no items in your shopping cart.

Return to Previous Page

Availability: In stock

Hepcidin-25 (human) trifluoroacetate salt
H-Asp-Thr-His-Phe-Pro-Ile-Cys-Ile-Phe-Cys-Cys-Gly-Cys-Cys-His-Arg-Ser-Lys-Cys-Gly-Met-Cys-Cys-Lys-Thr-OH trifluoroacetate salt
(Disulfide bonds between Cys⁷ and Cys²³/Cys¹⁰ and Cys¹³/Cys¹¹ and Cys¹⁹/Cys¹⁴ and Cys²²)

H-5926

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-5926.0100 0.1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 200.00
CHF 186.00 (7%)
H-5926.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 618.00
CHF 574.74 (7%)
H-5926.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 979.00
CHF 910.47 (7%)
Add to Wish List
Add to Compare

Details

Hepcidin-25 (hepatic bactericidal protein), also referred to as LEAP-1 (liver-expressed antimicrobial peptide) has been independently discovered by two groups in human blood ultrafiltrate and urine. The peptide which is predominantly expressed in the liver, belongs to a new vertebrate family of small antimicrobial peptides that contain 8 cysteine residues and show significant antibacterial and antifungal activity. Further investigations revealed that hepicidin is the principal iron-regulatory hormone in humans. Hepcidin acts by binding to the iron exporter ferroportin, inducing its internalization and degradation, thereby blocking cellular iron efflux. Nemeth et al. demonstrated that the N-terminal part of the peptide hormone is essential for its activity.
Former CAS-number 342790-21-0.
Item Number 4040671
APC Number 87-9-65
One Letter Code DTHFPICIFCCGCCHRSKCGMCCKT
Synonyms LEAP-1 (human), Hepc25 (human), Liver-Expressed Antimicrobial Peptide (human), PLTR (human), Putative Liver Tumor Regressor (human)
Molecular Formula C₁₁₃H₁₇₀N₃₄O₃₁S₉
Relative Molecular Mass 2789.40
CAS Registry Number [1356390-47-0] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Principal iron-regulatory hormone; Antimicrobial peptide