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Availability: In stock

L-685,458 trifluoroacetate salt
[(2R,4R,5S)-2-Benzyl-5-(Boc-amino)-4-hydroxy-6-phenyl-hexanoyl]-Leu-Phe-NH₂ trifluoroacetate salt

H-5106

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-5106.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 397.00
CHF 369.21 (7%)
H-5106.0005 5 mg Ships within 1 business day  
CHF 1'443.00
CHF 1'341.99 (7%)
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Details

L-685458, Boc-F-psi[CHOH-CH₂]-FFLF-NH₂, a potent γ-secretase inhibitor contains a hydroxyethylene equivalent of the Phe-Phe motif. The hydroxymethylene isostere may act as a transition analog to direct the inhibitor to the active site of an aspartyl protease target. L-685458 has been used to prepare photoaffinity probes that label the active site of γ-secretase.
Item Number 4034722
Molecular Formula C₃₉H₅₂N₄O₆
Relative Molecular Mass 672.87
CAS Registry Number [292632-98-5] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease

H-5106

Enzyme Substrates Inhibitors
γ-Secretase