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Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-5062.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 735.00
CHF 683.55 (7%)
H-5062.0005 5 mg Ships within 3-5 business days  
CHF 2,942.00
CHF 2,736.06 (7%)
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(Glu⁸·⁹)-Helodermin has been isolated from the salivary gland of the Gila monster Heloderma suspectum. It consists of 35 amino acids and shares 53 and 42% homology with human pituitary adenylate cyclase activating polypeptide (PACAP) and vasoactive intestinal peptide (VIP), respectively. It was shown to have high affinity for the mammalian VIP₂ receptor and equal potency and efficacy for stimulating cAMP production compared with mammalian VIP and PACAP. Even a helodermin-preferring receptor has been described. Furthermore, immunohistochemical studies, using antibodies that did not cross-react with mammalian VIP or PACAP or other known members of the GLP-1 / VIP / PACAP peptide family suggested the existence of a mammalian homologue to (Glu⁸·⁹)-Helodermin distinct from VIP and PACAP.
Item Number 4035320
APC Number 73-0-12
Molecular Formula C₁₇₆H₂₈₃N₄₅O₅₁
Relative Molecular Mass 3845.46
CAS Registry Number [209340-47-6]
Source Synthetic
Storage Conditions -20 ± 5 °C