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Availability: In stock

Ac-Ala-Leu-Cys-Asp-Asp-Pro-Arg-Val-Asp-Arg-Trp-Tyr-Cys-Gln-Phe-Val-Glu-Gly-NH₂ (Disulfide bond)

H-4902

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-4902.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 577.00
CHF 536.61 (7%)
H-4902.0005 5 mg Ships within 3-5 business days  
CHF 2'307.00
CHF 2'145.51 (7%)
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Details

The potent anticoagulant E-76, Acetyl-ALCDDPRVDRWYCQFVEG-amide, is an inhibitor of coagulation factor VIIa. It has been suggested that E-76 works by binding to an exosite on the factor VIIa protease domain, and non-competitively inhibits activation of factor X and amidolytic activity. E-76 has a well defined structure in solution determined by NMR spectroscopy that is similar to the X-ray crystal structure when complexed with factor VIIa and represents a new framework for the development of inhibitors for serine proteases.
Item Number 4033397
One Letter Code Ac-ALCDDPRVDRWYCQFVEG-NH₂
Synonyms E-76
Molecular Formula C₉₇H₁₃₉N₂₇O₂₉S₂
Relative Molecular Mass 2211.47
CAS Registry Number [1926163-13-4]
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Inhibitor of coagulation factor VIIa

H-4902

Enzyme Substrates Inhibitors
Coagulation Factor VIIa