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Phenylacetyl-(D-Arg²·²⁸,p-chloro-Phe⁶,Arg⁹,Abu¹⁵,Nle²⁷,Homoarg²⁹)-GRF (1-29) amide (human)
Phenylac-Tyr-D-Arg-Asp-Ala-Ile-p-chloro-Phe-Thr-Asn-Arg-Tyr-Arg-Lys-Val-Leu-Abu-Gln-Leu-Ser-Ala-Arg-Lys-Leu-Leu-Gln-Asp-Ile-Nle-D-Arg-Homoarg-NH₂

H-4884

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-4884.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 814.00
CHF 757.02 (7%)
H-4884.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1'463.00
CHF 1'360.59 (7%)
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Details

JV-1-36 exhibited high antagonistic activity against human growth hormone-releasing hormone (hGH-RH) in vitro and induced a strong and prolonged inhibition of GH release in vivo for at least 30 min. When administered s.c. into nude mice bearing xenografts of H-69 small cell lung carcinoma, JV-1-36 reduced significantly (P < 0.05) tumor volume and weight, after 31 days of therapy, as compared with controls. Antagonists of this structure are possible candidates for clinical application in the treatment of cancers dependent on insulin-like growth factors I and II.
Item Number 4034001
Synonyms JV-1-36, Phenylacetyl-(D-Arg²·²⁸,p-chloro-Phe⁶,Arg⁹,Abu¹⁵,Nle²⁷,Homoarg²⁹)-Sermorelin
Molecular Formula C₁₇₀H₂₈₀ClN₅₃O₄₁
Relative Molecular Mass 3757.88
CAS Registry Number [221377-59-9]
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Cancer Research
Growth Factors