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(Asn⁶⁷⁰,Sta⁶⁷¹,Val⁶⁷²)-Amyloid β/A4 Protein Precursor₇₇₀ (662-675) ammonium salt
H-Lys-Thr-Glu-Glu-Ile-Ser-Glu-Val-Asn-Sta-Val-Ala-Glu-Phe-OH ammonium salt

H-4848

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-4848.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 132.00
CHF 122.76 (7%)
H-4848.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 525.00
CHF 488.25 (7%)
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Details

Amyloid precursor protein (APP) β-secretase from human brain cleaves full-length APP at the amino terminus of the amyloid β-protein (Aβ) sequence, thus leading to the generation and extracellular release of β-cleaved soluble APP and a corresponding cell-associated carboxy-terminal fragment. The subsequent cleavage of the C-terminal fragment by γ-secretase(s) leads to the formation of Aβ. This new peptide represents a potent substrate analog inhibitor of APP β-secretase with IC₅₀ = 30 nM.
Item Number 4029489
Synonyms (Asn⁶⁷⁰,Sta⁶⁷¹,Val⁶⁷²)-APP₇₇₀ (662-675)
Molecular Formula C₇₃H₁₁₈N₁₆O₂₇
Relative Molecular Mass 1651.83
CAS Registry Number [350228-37-4] net
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Alzheimer's Disease

H-4848

Enzyme Substrates Inhibitors
β-Secretase