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Ac-Phe-Glu-Trp-Thr-Pro-Gly-Trp-Tyr-Gln-L-azetidine-2-carbonyl-Tyr-Ala-Leu-Pro-Leu-NH₂

H-4146

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-4146.0500 0.5 mg Ships within 3-5 business days  
CHF 577.00
CHF 536.61 (7%)
H-4146.1000 1 mg Ships within 3-5 business days  
CHF 1'030.00
CHF 957.90 (7%)
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Details

AF12198 exhibited both in vitro and in vivo IL-1 antagonist activity. It selectively bound the human type I IL-1 receptor but not the human type II receptor or the murine type I receptor. In vitro, AF12198 inhibited IL-1-induced IL-8 production by human dermal fibroblasts with an IC₅₀ of 25 nM and IL-1-induced intercellular adhesion molecule-1 expression by endothelial cells with an IC₅₀ of 9 nM. In vivo it blocked ex-vivo IL-1 induction of IL-6 and down modulates in vivo induction of IL-6. This is the first small molecule which shows IL-1 receptor antagonist activity in vivo.
Item Number 4028110
One Letter Code Ac-FEWTPGWYQ-Aze-YALPL-NH₂
Synonyms AF12198
Molecular Formula C₉₆H₁₂₃N₁₉O₂₂
Relative Molecular Mass 1895.15
CAS Registry Number [185413-30-3]
Source Synthetic
Storage Conditions -20 ± 5 °C