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Cyclo(-Gly-Asn-Trp-His-Gly-Thr-Ala-Pro-Asp)-Trp-Val-Tyr-Phe-Ala-His-Leu-Asp-Ile-Ile-Trp-OH

H-4074

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-4074.0500 0.5 mg Ships within 3-5 business days  
CHF 690.00
CHF 641.70 (7%)
H-4074.1000 1 mg Ships within 3-5 business days  
CHF 1'236.00
CHF 1'149.48 (7%)
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Details

The C-terminal sequence of this hybrid peptide corresponds to (Ala¹⁵)ET-1 (12-21), and the N-terminal sequence is derived from RES-701-1, an endothelin type B (ET-B) receptor antagonist of microbial origin. This hybrid peptide showed a selectivity for the type B receptor and inhibited ET-1 binding to ET-B receptor with an IC₅₀ value of 0.24 nM.
Item Number 4027880
One Letter Code c(GNWHGTAPD)WVYFAHLDIIW
Molecular Formula C₁₁₇H₁₅₀N₂₈O₂₇
Relative Molecular Mass 2380.65
CAS Registry Number [151308-48-4]
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Endothelin antagonist

Product citations

T.Suzawa et al., Bioorg. Med. Chem. Lett., 7, 1715 (1997)
K.Shibata et al., Peptide Chemistry 1995, Proceedings of the 33rd Symposium on Peptide Chemistry, Sapporo, Japan, p. 281, N.Nishi, ed., Osaka, Japan, (1996)