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H-4058

Availability: In stock

(Cyclo(Glu²²-Lys²⁶),Leu²⁷)-pTH (1-31) amide (human)
H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-cyclo(-Glu-Trp-Leu-Arg-Lys)-Leu-Leu-Gln-Asp-Val-NH₂
(cyclized between γ-Glu²² and ε-Lys²⁶)

H-4058

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-4058.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 927.00
CHF 862.11 (7%)
H-4058.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1'669.00
CHF 1'552.17 (7%)
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Details

Lactam analog of H-3408. ZT-031 exhibited an adenylyl cyclase activity (EC₅₀) of 3.3 ± 0.3 nM measured in rat osteosarcoma 17/2 cells and was therefore 6-fold more active than H-3408. The pTH analog has been evaluated for the treatment of osteoporosis and psoriasis.
Item Number 4027864
Molecular Formula C₁₆₂H₂₆₇N₄₉O₄₅S₂
Relative Molecular Mass 3685.34
CAS Registry Number [188899-65-2]
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Cosmetic Peptides & Dermatology
Osteoporosis Research
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Product citations

L.A.Sorbera, Drugs Future, 31, 670 (2006)
J.F.Whitfield, Curr Opin Investig Drugs, 7, 349 (2006)
J.-R.Barbier et al., J. Med. Chem., 40, 1373 (1997)