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Availability: In stock

H-Cys-Val-2-Nal-Met-OH

H-3552

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-3552.0001 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 113.00
CHF 105.09 (7%)
H-3552.0005 5 mg Ships within 3-5 business days  
CHF 453.00
CHF 421.29 (7%)
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Details

Disruption of the function of the Ras oncogene represents a target in the search of anticancer agents. This peptidomimetic derivative is the most potent synthetic inhibitor of p21ras farnesyltransferase (Ftase). It inhibited rat brain Ras Ftase activity in a dosedependent manner with an IC₅₀ value of 12 nM. Aromatic ring replacement by naphthylalanine maintained the intrinsic potency.
Item Number 4026862
APC Number 13-1-16
Molecular Formula C₂₆H₃₆N₄O₅S₂
Relative Molecular Mass 548.73
CAS Registry Number [158022-12-9]
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Ras farnesyltransferase inhibitor
Areas of Interest Cancer Research

Product citations

A.D.Hamilton and S.M.Sebti, Drug News & Perspect., 8, 138 (1995)
K.Leftheris et al., Bioorg. Med. Chem. Lett., 4, 887 (1994)

H-3552

Enzyme Substrates Inhibitors
Farnesyl-Diphosphate Farnesyltransferase