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Availability: In stock

Grb2 SH2 Domain Ligand
H-Tyr(PO₃H₂)-Val-Asn-Val-OH

H-2708

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-2708.0001 1 mg Ships within 3-5 business days  
CHF 357.00
CHF 332.01 (7%)
H-2708.0005 5 mg Ships within 3-5 business days  
CHF 1,429.00
CHF 1,328.97 (7%)
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Details

pYVNV corresponds to residues 317 to 320 of the oncogenic protein Shc. Similar phosphotyrosine motifs are also found in receptor tyrosine kinases and substrates of them. This peptide binds with high affinity (18 nM) to the SH2 domain of the growth factor bound-2 protein (Grb2). It is a useful inhibitor of the interaction of Grb2 with Shc, or with other Grb-2-binding proteins involved in the cell signaling cascade.
Item Number 4026417
Molecular Formula C₂₃H₃₆N₅O₁₀P
Relative Molecular Mass 573.54
CAS Registry Number [168423-05-0]
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Protein-Tyrosine Kinases