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Galanin (1-13)-Pro-Pro-(Ala-Leu-)₂Ala amide
H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Pro-Pro-Pro-Ala-Leu-Ala-Leu-Ala-NH₂

H-2576

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-2576.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 206.00
CHF 191.58 (7%)
H-2576.1000 1 mg Ships within 3-5 business days  
CHF 361.00
CHF 335.73 (7%)
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Details

M40, a peptide containing the N-terminal galanin sequence (1-13), is an antagonist of the galanin receptor. M40 significantly antagonized galanin-induced feeding behavior at doses approximately equimolar to the active doses of rat galanin. M40 inhibited the binding of (¹²⁵I-Tyr²⁶)-galanin (porcine) in rat hypothalamic membranes with an IC₅₀ value of 15 nM.
Coadministration of M40 with a muscarinic M1 agonist may enhance the efficacy of cholinergic treatments for the cognitive deficits of Alzheimer disease.
Item Number 4030654
APC Number 46-1-19
One Letter Code GWTLNSAGYLLGPPPALALA-NH₂
Synonyms M40
Molecular Formula C₉₄H₁₄₅N₂₃O₂₄
Relative Molecular Mass 1981.33
CAS Registry Number [143896-17-7]
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Galanin antagonist