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Cyclo(-Gly-Asn-Trp-His-Gly-Thr-Ala-Pro-Asp)-Trp-Phe-Phe-Asn-Tyr-Tyr-Trp-OH

H-2508

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-2508.0500 0.5 mg Ships within 3-5 business days  
CHF 690.00
CHF 641.70 (7%)
H-2508.1000 1 mg Ships within 3-5 business days  
CHF 1'236.00
CHF 1'149.48 (7%)
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Details

The cyclic peptide RES-701-1, originally isolated from the culture broth of Streptomyces sp. RE-701, shows high selectivity for ET-B receptors. RES-701-1 inhibited ET-1 binding to ET-B receptors with an IC₅₀ value of 10 nM and blocked ET-B receptor-mediated responses. It may provide a powerful tool for understanding the physiological roles of the ET-B receptor.
Item Number 4026078
APC Number 88-2-51
Synonyms RES-701-1
Molecular Formula C₁₀₃H₁₁₅N₂₃O₂₃
Relative Molecular Mass 2043.19
CAS Registry Number [151308-34-8]
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Endothelin antagonist

Product citations

H.Karaki and Y.Matsuda, Cardiovasc. Drug Rev., 14, 17 (1996)