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Availability: In stock

Ac-Asp-Glu-Val-Asp-aldehyde (pseudo acid)

H-2496

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-2496.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 206.00
CHF 191.58 (7%)
H-2496.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 824.00
CHF 766.32 (7%)
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Details

Ac-DEVD-CHO is a potent inhibitor of the poly(ADP-ribose) polymerase (PARP) cleavage by caspase-3 (IC₅₀ = 0.2 nM). PARP cleavage occurs at the onset of apoptosis. The peptide aldehyde was able to attenuate apoptotic events in vitro (IC₅₀ = 10 to 100 nM).
Item Number 4026022
APC Number 81-6-31
One Letter Code Ac-DEVD-CHO
Synonyms Ac-DEVD-CHO
Molecular Formula C₂₀H₃₀N₄O₁₁
Relative Molecular Mass 502.48
CAS Registry Number [184179-08-6]
Source Synthetic
Storage Conditions -20 ± 5 °C
Keywords Caspase-3 inhibitor
Areas of Interest Apoptosis & Necrosis

H-2496

Enzyme Substrates Inhibitors
Caspase-3 (CPP-32; Yama; Apopain)    
Caspase-6 (Mch2)    
Caspase-8 (MACH; FLICE; Mch5)    
Caspase-9 (ICE-LAP6; Mch6)    
Caspase-10    
Caspase-1 (ICE)    
Caspase-7 (ICE-LAP3; Mch3; CMH-1)