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Margatoxin
H-Thr-Ile-Ile-Asn-Val-Lys-Cys-Thr-Ser-Pro-Lys-Gln-Cys-Leu-Pro-Pro-Cys-Lys-Ala-Gln-Phe-Gly-Gln-Ser-Ala-Gly-Ala-Lys-Cys-Met-Asn-Gly-Lys-Cys-Lys-Cys-Tyr-Pro-His-OH
(Disulfide bonds between Cys⁷ and Cys²⁹/Cys¹³ and Cys³⁴/Cys¹⁷ and Cys³⁶)

H-2192

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-2192.0100 0.1 mg Ships within 3-5 business days  
CHF 464.00
CHF 431.52 (7%)
H-2192.0500 0.5 mg Ships within 1 business day  
CHF 1'391.00
CHF 1'293.63 (7%)
H-2192.1000 1 mg Ships within 3-5 business days  
CHF 2'472.00
CHF 2'298.96 (7%)
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Details

Margatoxin (MgTX), originally isolated from the venom of the scorpion Centruroides margaritatus, is a peptidyl inhibitor of voltage dependent K⁺ channels in brain synaptic plasma membranes. MgTX blocks the n-type current of human T-lymphocytes (IC₅₀ = 50 pM, 20 fold more potent than charybdotoxin), has a lower dissociation rate and has no effect on Ca²⁺ activated channels. MgTX is therefore a useful tool to study the physiologic role of K⁺ channels.
Item Number 4030845
One Letter Code TIINVKCTSPKQCLPPCKAQFGQSAGAKCMNGKCKCYPH
Molecular Formula C₁₇₈H₂₈₆N₅₂O₅₀S₇
Relative Molecular Mass 4179.01
CAS Registry Number [145808-47-5]
Source Synthetic
Storage Conditions -20 ± 5 °C
Areas of Interest Ion Channel Modulating Agents