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Uroguanylin Topoisomer A (human) trifluoroacetate salt
H-Asn-Asp-Asp-Cys-Glu-Leu-Cys-Val-Asn-Val-Ala-Cys-Thr-Gly-Cys-Leu-OH trifluoroacetate salt
(Disulfide bonds between Cys⁴ and Cys¹²/Cys⁷ and Cys¹⁵)

H-2166

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-2166.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 433.00
CHF 402.69 (7%)
H-2166.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 773.00
CHF 718.89 (7%)
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Details

Uroguanylin belongs to the guanylin family of cyclic guanosine monophosphate (cGMP) regulating peptides. This family of peptides shows homology to the heat stable enterotoxins produced by strains of Escherichia coli and other enteric bacteria that cause a secretory form of diarrhea. Along with the isolation of uroguanylin from urine and the subsequent demonstration of its natriuretic activity by direct effects on the kidney, uroguanylin has been suggested to play a role in the physiological maintenance of sodium balance in vivo.
Uroguanylin activation of the guanylate cyclase-C/cyclic guanosine monophosphate pathway elicited analgesic effects in animal models of colonic hypersensitivity, unraveling a novel pathway to treat abdominal pain (Silos-Santiago et al. (2013)).
Item Number 4030148
APC Number 43-0-14
One Letter Code NDDCELCVNVACTGCL
Synonyms UGN (human), UGN Topoisomer A (human)
Molecular Formula C₆₄H₁₀₂N₁₈O₂₆S₄
Relative Molecular Mass 1667.88
CAS Registry Number [154525-25-4] net
Source Synthetic
Storage Conditions -20 ± 5 °C