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Availability: In stock

Endotoxin Inhibitor
H-Lys-Thr-Lys-Cys-Lys-Phe-Leu-Lys-Lys-Cys-OH
(Disulfide bond)

H-1382

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-1382.0001 1 mg Ships within 3-5 business days  
CHF 70.00
CHF 65.10 (7%)
H-1382.0005 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 245.00
CHF 227.85 (7%)
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Details

The cyclic peptide KTKCKFLKKC has ben shown to form a strong complex with lipid A, the toxic component of the endotoxin lipopolysaccharide (LPS) with Ka = 0.56 · 10⁷ M⁻¹. It detoxifies LPS in vitro and prevents LPS-induced cytokine release and lethality in vivo. Furthermore, it shows neither antibiotic activity nor toxicity and might therefore be useful in the prophylaxis and treatment of LPS-mediated diseases.
KTKCKFLKKC bears a structural resemblance to the peptide antibiotic and endotoxin inhibitor polymyxin B. It could be of use as an adjuvant for antibiotic therapy.
Item Number 4014453
APC Number 74-1-26
One Letter Code KTKCKFLKKC
Synonyms K-T-K-C-K-F-L-K-K-C
Molecular Formula C₅₅H₉₇N₁₅O₁₂S₂
Relative Molecular Mass 1224.60
CAS Registry Number [147396-10-9]
Source Synthetic
Storage Conditions -20 ± 5 °C