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Amyloid β-Protein (1-42)
H-Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala-OH

H-1368

Product No. Pack Size Available ADS InfoAnalytical Data Sheet Unit Price Online Order Price Qty
H-1368.0100 0.1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 100.00
CHF 93.00 (7%)
H-1368.0500 0.5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 330.00
CHF 306.90 (7%)
H-1368.1000 1 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 495.00
CHF 460.35 (7%)
H-1368.5000 5 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 1'885.00
CHF 1'753.05 (7%)
H-1368.0010 10 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 3'205.00
CHF 2'980.65 (7%)
H-1368.0025 25 mg Ships within 1 business day ADSExemplary Data Sheet of a current available lot.
CHF 7'678.00
CHF 7'140.54 (7%)
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Details

Aβ 1-42, 42-residue fragment of amyloid precursor protein, has been found to be a major constituent of the senile plaques formed in the brains of patients with Alzheimer's disease and late Down's syndrome. Aβ 1-42 readily forms neurotoxic oligomers at physiological pH. On the other hand, the peptide shows antimicrobial activity. The sequence of H-1368 corresponds to the human, bovine, canine, feline, ovine, guinea pig, and rabbit Aβ42 peptide.
The peptide has been used to detect amyloid β-protein multimers in the cerebrospinal fluid of Alzheimer's disease patients through fluorescence correlation spectroscopy.
For detailed descriptions of the preparation of Aβ 1-42 monomers and protofibrils please see the papers of Jan, Hartley, and Lashuel, Stine et al. (2011), and of Broersen and colleagues. The findings of Ryan et al. indicate that 10% ammonia disaggregates Aβ42 more efficiently than HFIP.
Item Number 4014447
One Letter Code DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
Synonyms Aβ42, β-Amyloid (1-42)
Molecular Formula C₂₀₃H₃₁₁N₅₅O₆₀S
Relative Molecular Mass 4514.10
CAS Registry Number [107761-42-2]
Source Synthetic
Storage Conditions -20 ± 5 °C

Bachem product citations

Y.Chen et al., Molecules, 21, 323 (2016)