N-2010
Z-Val-Arg-Pro-DL-Arg-fluoromethylketone
Trifluoroacetate salt
Synonym:
MALT1 Inhibitor, Z-VRPR-FMK
| C31H49FN10O6 | Mr: 676.79 | |
| Longterm storage temperature: | -20 ± 5 °C | C31H49FN10O6 |
Cell-permeable, irreversible inhibitor of paracaspase MALT1. The inhibitor was based on the sequence of a published optimal tetrapeptide substrate for the A. thaliana metacaspase AtMC9.
Literature:
D.Vercammen et al., J. Mol. Biol., 364, 625 (2006)
F.Rebeaud et al., Nat. Immunol., 9, 272 (2008)
S.I.Gringhuis et al., PLoS Pathogens, 7, e1001259 (2011)
D.Vercammen et al., J. Mol. Biol., 364, 625 (2006)
F.Rebeaud et al., Nat. Immunol., 9, 272 (2008)
S.I.Gringhuis et al., PLoS Pathogens, 7, e1001259 (2011)
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Family Description:
Nomenclature of Caspases (Cysteine-dependent aspartate-directed proteases):
Caspase-1 ... ICE
Caspase-2 ... ICH-1
Caspase-3 ... CPP-32, Yama, Apopain
Caspase-4 ... TX, ICH-2, ICErel-II
Caspase-5 ... ICErel-III, TY
Caspase-6 ... Mch2
Caspase-7 ... Mch3, ICE-LAP3, CMH-1
Caspase-8 ... MACH, FLICE, Mch5
Caspase-9 ... ICE-LAP6, Mch6
Caspase-10 ... Mch4
Family Literature:
E.S.Alnemri et al., Cell, 87, 171 (1996)
N.Margolin et al., J. Biol. Chem., 272, 7223 (1997)
R.V.Talanian et al., J. Biol. Chem., 272, 9677 (1997)
G.M.Cohen, Biochem. J., 326, 1 (1997)
D.K.Miller, Semin. Immunol., 9, 35 (1997)
D.W.Nicholson and N.A.Thornberry, Trends Biochem. Sci., 22, 299 (1997)
B.B.Wolf et al., J. Biol. Chem., 274, 20049 (1999)
R.V.Talanian et al., J. Med. Chem., 43, 3351 (2000)
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