H-6795
GLP-1 (7-36) amide (human, bovine, guinea pig, mouse, rat)
H-His-Ala-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Val-Ser-Ser-Tyr-Leu-Glu-Gly-Gln-Ala-Ala-Lys-Glu-Phe-Ile-Ala-Trp-Leu-Val-Lys-Gly-Arg-NH2
Trifluoroacetate salt
Also available as cGMP API.
Synonym:
Glucagon-Like Peptide 1 (7-36) amide (human, bovine, guinea pig, mouse, rat), Preproglucagon (98-127) amide (human, bovine, guinea pig, mouse, rat), Proglucagon (78-107) amide (human, bovine, guinea pig, mouse, rat)
| C149H226N40O45 | Mr: 3297.68 | [107444-51-9] net |
| Longterm storage temperature: | -20 ± 5 °C | C149H226N40O45 |
This GLP-1 fragment is secreted from the lower small intestine and shows a strong insulinotropic effect. GLP-1 (7-36) amide is considered as the most important incretin hormone. Its action is mediated by receptors expressed by the endocrine pancreatic B-cells. Considerable interest has focused on the development of this peptide as a therapeutic strategy for non-insulin-dependent (type 2 ) diabetes mellitus and associated neuropathy.
Literature:
G.I.Bell et al., Nature, 304, 368 (1983)
B.Kreymann et al., Lancet, 2, 1300 (1987)
C.Orskov and J.H.Nielsen, FEBS Lett., 229, 175 (1988)
J.-P.Raufman et al., J. Biol. Chem., 267, 21432 (1992)
P.A.Martin and A.Faulkner, Comp. Biochem. Biophys., 105A, 705 (1993)
H.C.Fehmann et al., Peptides, 15, 453 (1994)
M.A.Nauck et al., Exp. Clin. Endocrinol. Diabetes, 105, 187 (1997)
T.-A.Perry and N.H.Greig, Trends Pharmacol. Sci., 24, 377 (2003)
J.J.Meier et al., Biodrugs, 17, 93 (2003)
L.Brunetti et al., Peptides, 29, 1377 (2008)
G.I.Bell et al., Nature, 304, 368 (1983)
B.Kreymann et al., Lancet, 2, 1300 (1987)
C.Orskov and J.H.Nielsen, FEBS Lett., 229, 175 (1988)
J.-P.Raufman et al., J. Biol. Chem., 267, 21432 (1992)
P.A.Martin and A.Faulkner, Comp. Biochem. Biophys., 105A, 705 (1993)
H.C.Fehmann et al., Peptides, 15, 453 (1994)
M.A.Nauck et al., Exp. Clin. Endocrinol. Diabetes, 105, 187 (1997)
T.-A.Perry and N.H.Greig, Trends Pharmacol. Sci., 24, 377 (2003)
J.J.Meier et al., Biodrugs, 17, 93 (2003)
L.Brunetti et al., Peptides, 29, 1377 (2008)
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Family Description:
For the long-acting GLP-1 analog liraglutide see H-6724.
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