H-6784
Relaxin H2 (human)
(Pyr-Leu-Tyr-Ser-Ala-Leu-Ala-Asn-Lys-Cys-Cys-His-Val-Gly-Cys-Thr-Lys-Arg-Ser-Leu-Ala-Arg-Phe-Cys-OH)A(H-Asp-Ser-Trp-Met-Glu-Glu-Val-Ile-Lys-Leu-Cys-Gly-Arg-Glu-Leu-Val-Arg-Ala-Gln-Ile-Ala-Ile-Cys-Gly-Met-Ser-Thr-Trp-Ser-OH)B
(Disulfide bonds between Cys¹⁰A and Cys¹⁵A/Cys¹¹A and Cys¹¹B/Cys²⁴A and Cys²³B)
Trifluoroacetate salt
| C256H408N74O74S8 | Mr: 5963.04 | [99489-94-8] net |
| Longterm storage temperature: | -20 ± 5 °C | C256H408N74O74S8 |
Relaxin H2 is the major stored and circulating isoform of the peptide hormone relaxin in humans. This pregnancy hormone has also shown cardioprotective activity. The observed long-term effects of relaxin H2 on connective tissues may be due to alterations in the turnover of collagen and proteoglycans.
Literature:
P.L.Osheroff et al., Proc. Natl. Acad. Sci. USA, 89, 2384 (1992)
X.Qin et al., Biol. Reprod., 56, 800 (1997)
S.Kapila, J. Musculoskelet. Neuronal Interact., 3, 401 (2003)
A.Shpakov et al., Ann. NY Acad. Sci., 1041, 305 (2005)
C.S.Samuel and T.D.Hewitson, Kidney Int., 69, 1498 (2006)
X.-l.Moore et al., Endocrinology, 148, 1582 (2007)
L.T.Goldsmith and G.Weiss, Ann. NY Acad. Sci., 1160, 130 (2009)
P.L.Osheroff et al., Proc. Natl. Acad. Sci. USA, 89, 2384 (1992)
X.Qin et al., Biol. Reprod., 56, 800 (1997)
S.Kapila, J. Musculoskelet. Neuronal Interact., 3, 401 (2003)
A.Shpakov et al., Ann. NY Acad. Sci., 1041, 305 (2005)
C.S.Samuel and T.D.Hewitson, Kidney Int., 69, 1498 (2006)
X.-l.Moore et al., Endocrinology, 148, 1582 (2007)
L.T.Goldsmith and G.Weiss, Ann. NY Acad. Sci., 1160, 130 (2009)
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