H-6734
Maxadilan
H-Cys-Asp-Ala-Thr-Cys-Gln-Phe-Arg-Lys-Ala-Ile-Asp-Asp-Cys-Gln-Lys-Gln-Ala-His-His-Ser-Asn-Val-Leu-Gln-Thr-Ser-Val-Gln-Thr-Thr-Ala-Thr-Phe-Thr-Ser-Met-Asp-Thr-Ser-Gln-Leu-Pro-Gly-Asn-Ser-Val-Phe-Lys-Glu-Cys-Met-Lys-Gln-Lys-Lys-Lys-Glu-Phe-Lys-Ala-NH2
(Disulfide bonds between Cys¹ and Cys⁵/Cys¹⁴ and Cys⁵¹)
Trifluoroacetate salt
| C291H466N86O94S6 | Mr: 6865.82 | [135374-80-0] net |
| Longterm storage temperature: | -20 ± 5 °C | C291H466N86O94S6 |
Maxadilan, isolated from the salivary gland of the sand fly Lutzomyia longipalpis, is a potent vasodilator. The peptide specifically and potently activates the mammalian PAC1 receptor, one of the three receptors for PACAP.
Literature:
E.A.Lerner and C.B.Shoemaker, J. Biol. Chem., 267, 1062 (1992)
M.B.P.Soares et al., J. Immunol., 160, 1811 (1998)
I.Tatsuno et al., Brain Res., 889, 138 (2001)
E.A.Lerner et al., Peptides, 28, 1651 (2007)
E.A.Lerner and C.B.Shoemaker, J. Biol. Chem., 267, 1062 (1992)
M.B.P.Soares et al., J. Immunol., 160, 1811 (1998)
I.Tatsuno et al., Brain Res., 889, 138 (2001)
E.A.Lerner et al., Peptides, 28, 1651 (2007)
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