H-6708
AF-16 (human, mouse, rat)
H-Val-Cys-His-Ser-Lys-Thr-Arg-Ser-Asn-Pro-Glu-Asn-Asn-Val-Gly-Leu-OH
Trifluoroacetate salt
Synonym:
AF-16, Antisecretory Factor-1 (36-51) (human, mouse, rat), ASF (36-51) (human, mouse, rat), AF (36-51) (human, mouse, rat), Multiubiquitin Chain Binding Protein (36-51) (human, mouse, rat), RPN10 (36-51) (human, mouse, rat), 26S Proteasome Regulatory Subunit S5A (36-51) (human, mouse, rat)
| C71H119N25O25S | Mr: 1754.95 | [188585-60-6] net |
| Longterm storage temperature: | -20 ± 5 °C | C71H119N25O25S |
AF-16 comprises the active site region (I)VCHSKTR of the antisecretory factor protein known to inhibit intestinal fluid secretion induced by cholera toxin. The peptide was shown to abolish sickness and death in experimental herpes simplex encephalitis by reducing increase of intracranial pressure.
Literature:
E.Johansson et al., J. Biol. Chem., 270, 20615 (1995)
E.Johansson et al., Biochim. Biophys. Acta, 1362, 177 (1997)
E.Jennische et al., Brain Res., 1227, 189 (2008)
E.Johansson et al., J. Biol. Chem., 270, 20615 (1995)
E.Johansson et al., Biochim. Biophys. Acta, 1362, 177 (1997)
E.Jennische et al., Brain Res., 1227, 189 (2008)
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