H-6544
Met-
H-
(Disulfide bonds between Cys¹⁰ and Cys³⁴/Cys¹¹ and Cys⁵⁰)
Trifluoroacetate salt
| C355H543N97O101S6 | Mr: 7978.21 | |
| Longterm storage temperature: | -20 ± 5 °C |
Synthetic product. Potent antagonist of RANTES and macrophage inflammatory polypeptide-1α (MIP-1α). Met-RANTES inhibited RANTES- or MIP-1α-induced chemotaxis of promonocytic THP-1cells and T-cells. Although Met-RANTES antagonized RANTES and MIP-1α with similar potency in the chemotaxis response it showed a clear difference in the cytokine-induced calcium mobilization assay.
Literature:
A.E.I.Proudfoot et al., J. Biol. Chem., 271, 2599 (1996)
A.E.I.Proudfoot et al., J. Biol. Chem., 271, 2599 (1996)
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