H-2214
(Des-Cys1,cyclo(Ser2-Asu7))-Calcitonin (eel)
Cyclo(-Ser-Asn-Leu-Ser-Thr-Asu)-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asp-Val-Gly-Ala-Gly-Thr-Pro-NH2
Acetate salt
Also available as cGMP API.
Synonym:
Elcatonin, (Asu1·7)-Calcitonin (eel)
| C148H244N42O47 | Mr: 3363.82 | [60731-46-6] net |
| Longterm storage temperature: | -20 ± 5 °C | C148H244N42O47 |
Elcatonin, also known as carbocalcitonin, is the aminosuberic acid analog of eel calcitonin. It has all the biological properties of the corresponding natural calcitonin (H-2255). The substitution of the disulfide bond of natural calcitonins with an ethylene bridge in 1-7 N-terminal position gives elcatonin greater stability and excellent tolerability when used in vivo.
Literature:
A.Caniggia et al., Minerva Medica, 74, 993 (1983)
Italian Osteoporosis Network, Current Therapeutic Res., 45, 502 (1989)
A.Caniggia et al., Minerva Medica, 74, 993 (1983)
Italian Osteoporosis Network, Current Therapeutic Res., 45, 502 (1989)
|
Print