H-2095
Atrial Natriuretic Factor (1-28) (human)
H-Ser-Leu-Arg-Arg-Ser-Ser-Cys-Phe-Gly-Gly-Arg-Met-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-OH
(Disulfide bond)
Synonym:
αhANF, Carperitide
| C127H203N45O39S3 | Mr: 3080.49 | [89213-87-6] net |
| Longterm storage temperature: | -20 ± 5 °C | C127H203N45O39S3 |
ANP/ANF is synthesized in cardiac myocytes and is primarily released in response to atrial wall stretching and intravascular volume expansion. The peptide signals via the guanylate cyclase-linked natriuretic peptide receptor A (NPR-A) and plays an important role in blood pressure regulation and blood volume homeostasis. ANP/ANF exerts vasodilatory, diuretic, natriuretic, anti-inflammatory, antifibrotic and antimitogenic effects.
Literature:
S.Mukaddam-Daher, Expert Opin. Ther. Targets, 10, 239 (2006)
G.M.Felker et al., CMAJ, 175, 611 (2006)
S.Rubattu et al., Am. J. Hypertens., 21, 733 (2008)
S.Mukaddam-Daher, Expert Opin. Ther. Targets, 10, 239 (2006)
G.M.Felker et al., CMAJ, 175, 611 (2006)
S.Rubattu et al., Am. J. Hypertens., 21, 733 (2008)
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