H-1100
(Nle4,D-Phe7)-α-MSH
Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2
Trifluoroacetate salt
Also available as cGMP API.
Synonym:
Afamelanotide, NDP-MSH, Melanotan 1, CUV1647
| C78H111N21O19 | Mr: 1646.87 | [75921-69-6] net |
| Longterm storage temperature: | -20 ± 5 °C | C78H111N21O19 |
A synthetic analog of α-MSH which shows prolonged biological activity and is 26 times more active than α-MSH in the adenylate cyclase assay.
Literature:
T.K.Sawyer et al., Proc. Natl. Acad. Sci. USA, 77, 5754 (1980)
M.E.Hadley et al., Science, 213, 1025 (1981)
K.R.Gehlsen et al., Pigment Cell Res., 5, 219 (1992)
S.O.Ugwu et al., Biopharm. Drug Dispos., 18, 259 (1997)
R.T.Dorr et al., Arch. Dermatol., 140, 827 (2004)
M.E.Hadley and R.T.Dorr, Peptides, 27, 921 (2006)
T.K.Sawyer et al., Proc. Natl. Acad. Sci. USA, 77, 5754 (1980)
M.E.Hadley et al., Science, 213, 1025 (1981)
K.R.Gehlsen et al., Pigment Cell Res., 5, 219 (1992)
S.O.Ugwu et al., Biopharm. Drug Dispos., 18, 259 (1997)
R.T.Dorr et al., Arch. Dermatol., 140, 827 (2004)
M.E.Hadley and R.T.Dorr, Peptides, 27, 921 (2006)
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